Figure 2.
From the following article: An Introduction to the PANTHER Pathway Resource
Figure 2
PANTHER pathway module and its relationship to the PANTHER family/subfamily library module. A pathway molecule and molecular complex classes participate in a reaction, and a reaction is part of a pathway. Both pathways and molecule as well as complex classes are annotated with locations, either a cell type or cellular component. Since a reaction can span different cellular components (e.g., a transcription factor translocating from the cytosol to nucleus), the reaction itself is not annotated with a location. The pathway is linked to the PANTHER family/subfamily library module through the association of each pathway molecule class with one or more sequences in the library. Each sequence belongs to a subfamily, which indirectly links a pathway to a hidden Markov model (HMM), phylogenetic tree, and multiple sequence alignment (MSA).
